I know that Dino at least has one RG8 with the 808 pups in it. And it all depends on the type of sound the artist likes and even if he has a endorsment deal with a pup company. But mainly it will depend on the sound an artist likes which pups he will choose to have on his custom RG8 he gets. Same goes for the bodywood. If he wants a nice custom bodywood he will choose any other wood than basswood, because that is just the same he (or she) will be able to get from a "normal" RG2228. I myself would also go for another wood if I had the choice, mainly because I can and that it will give my RG8 a more custom feel.
I do think that the RG8 would be great with a mahogany body. You can hear the different characteristics of different bodywoods. Just compare a mahogany RG6 with a basswood RG6 by running it back-to-back through the same rig with identical settings. You will definately hear the difference. However, I do agree MaxOfMetal that the amp and the pups have a bigger impact on the sound.
I also think that you should be able to get a good clean sound and a good metal sound from the RG2228. And there are aftermarket 8 string pups available, so if the sound is not really what you hope or want, look around and see if there are other pups that would give you what your looking for tonewise. On the Bareknuckle site they have some sound clips that might help you out.
My Ibby's:
1975 2845 western acoustic
1977 2354S SG custom copy Mahogany
2002 RG7321 BK
1993 RG450 PN
2006 RGTHRG2 N.Y. City XI (Exotic)
2009 RGA32 MOL
2010 RGA42 BK
2005 SRX350 NT
Non-Ibby's:
1999 AriaProII MAC50 Tansparent Blue
1997 Manuel Serrang Spanish acoustic